Disposable technologies are substituting more conventional equipment throughout the biopharmaceutical manufacturing process. The lightweight, disposable, and fully customizable options permit use in both upstream and downstream processes. In addition, such disposable systems provide a less expensive alternative to costly stainless steel systems that require extensive cleaning validations. Furthermore, the disposable option eliminates product carry-over issues, which are of great concern when manufacturing in a multiproduct facility. This discussion will focus on integration of disposable systems into existing processes and the optimization of cleaning validation in a multiproduct biopharmaceutical pilot plant.