Over the history of the chemical industry, chemists and chemical engineers have worked together to discover and then scale-up new chemistries into commercial products and processes. Other engineering disciplines have contributed as well to address issues such as environmental protection, equipment design, and automation. Yet even today these historical roles between the sciences and engineering are changing due to global challenges to the environment and anticipated limitations on resource availability. And although these challenges offer new opportunities to re-invent the chemical industry, they suggest that a more holistic approach is needed to create a new generation of green chemistry products. The effects on the environment must be anticipated and incorporated at all stages in the development of new chemical products and processes. Advances in green chemistry and green engineering provide design principles and a hierarchical approach for the creation of environmentally sustainable products. This presentation will focus on environmentally conscious design and how its application has facilitated the commercialization of green chemistry innovations.