Wednesday, 16 May 2007 - 9:40 AM
207 (Pfahler Hall)
47

Development of an efficient, scaleable process for the tetrazole core of BMS-317180, a growth hormone secretagogue

Akin H. Davulcu, Zhongmin Zhu, Jollie D. Godfrey, Mark D. Schwinden, Rita Fox, Bharat P. Patel, Wendel W. Doubleday, and Rodney L. Parsons, Jr. Bristol-Myers Squibb Company, New Brunswick, NJ

The discovery, development and implementation of an efficient, scalable process for the preparation of the tetrazole core of BMS-317180 will be described. Key considerations in the development of this process focused on safety and the requirement for a complex, telescoped sequence to contend with the lack of crystalline intermediates.


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