David Vanderah, Mark Rocco, Marlon Walker, and Kenneth Rubinson. National Institute of Standards and Technology, Gaithersburg, MD
The self-assembled monolayers (SAMs) of the omega-methyl oligo(ethylene oxide) disulfide - OEO disulfide - [S(CH2CH2O)6CH3]2 {[S(EO)6]2} on Au from 95% ethanol and from 100% water are described. Spectroscopic ellipsometry and reflection-absorption infrared spectroscopy indicate the [S(EO)6]2 films are similar to the disordered films of HS(CH2CH2O)6CH3 {(EO)6} and HS(CH2)3O(CH2CH2O)5CH3 {C3EO5} at their protein adsorption minima. However, unlike the (EO)6 and C3EO5 thiols, the [S(EO)6]2 films are self-limiting in their surface packing density and sustain film thickness of 1.2 �b 0.2 nm, corresponding to 50% to 70% coverage, over extended periods of time. As a result, OEO disulfides offer an attractive motif for the generation of ultrathin, protein rejecting surfaces.
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