In looking for new therapies for Alzheimer's Disease (AD), γ-secretase is considered an important target. γ-Secretase is a protease that cleaves amyloid precursor protein. This cleavage results in amyloid β-peptides αβ40 and αβ42. There is considerable evidence that these amyloid peptides are involved in the progression of AD. A γ-secretase inhibitor is an approach to treat the disease, unlike current therapies which treat symptoms. A high-throughput screen (HTS) was conducted and subsequently a member of a new class of γ-secretase inhibitors was discovered. In the HTS follow-up, pyrimidine and pyridine analogues were also prepared in an attempt to improve physical properties. This work will present the synthetic pathways into these new scaffolds, which employed the use of Buchwald-type palladium-mediated amination reactions on chloro-heterocyles.