The GlaxoSmithKline (GSK) Worldwide Applied Technology Group (WW ATG) is one part of the equation for the microwave-assisted organic synthesis technology (MAOS) assessment and development within GSK. WW ATG is a transnational support group that partners across all of GSK's R&D and into manufacturing in the assessment and development of innovative and novel technology for our pharmaceutical R&D business. Our team is comprised of expertise in chemistry, applied physics, systems engineering and robotics, scientific instrumentation design, and general technology project management. We approach new MAOS applications by first developing a thorough understanding of the process by which GSK R&D scientists conduct their work. This presentation will cover our approach in the context of high-throughput MAOS, medicinal chemistry and our recent initiatives in MAOS scale-up.