Anton Paar USA introduces new accessories for efficient method development and high throughput approaches in our multimode batch reactor, the Synthos 3000.

In addition to the already established 48-position rotor, we present two new tools for reliable handling of small scale applications in microwave-assisted organic synthesis at elevated pressure. The Rotor 64MG5 offers simultaneous processing of up to 64 disposable screw-cap glass vials with an operation volume of 0.3 to 3.0 mL. Its operation limits of 200�C and 20 bar make it useful for method development and optimization processes. Furthermore we introduce a unique well-plate system allowing screening reactions in a 8x6 well format at elevated pressure. Using silicon carbide (SiC) as well-plate material even low-absorbing or microwave-transparent mixtures can be applied effectively.

As a proof of concept to demonstrate the excellent homogeneity of the electromagnetic field inside the cavity we performed a thermal sensitive esterification reaction.1 The results of the different equipments correspond nicely with previous single run experiments showing no significant deviation of conversion at the individual positions.

Those new tools extend the range of applications in the Synthos 3000 platform enabling microwave assisted synthesis from the smallest range up to multigram production in one single instrument.