Montmorillonite clay modified with amino acids is researched as a potential component to drug delivery systems in the future. In this work the interactions of the amino acids arginine and lysine with sodium montmorillonite were studied using theoretical molecular modeling methods. The interlayer spacing of montmorillonite was increased by incorporating water molecules and allowing the system to evolve with molecular mechanics. Care was taken to retain the sodium cations in the interlayer. The amino acid conformations were obtained surrounding the molecules with numerous discrete water molecules and minimizing the system at the semi empirical level. The optimized amino acids were then placed in the interlayer space in various initial positions. Molecular mechanics calculations were performed and the final positions were analyzed. Preliminary results tend to indicate the preponderance of configurations which include surface-sodium-amino acid complexes.