Wednesday, 16 May 2007
3rd Floor Hall (Pfahler Hall)
67

Reaction of thermolabile aryllithium reagents with isatoic anhydride

Joanne Bertonazzi, Lynn M. Bradley, and David A. Hunt. The College of New Jersey, Ewing, NJ

In an attempt to develop a novel route to dibenzoazepine derivatives, functionalized aryllithium reagents were added to isatoic anhydrides at low temperatures. Instead of isolating the desired tricycles, 2-amino benzophenone derivatives were isolated. A rationale for this observation will be discussed. Preliminary results from the reduction of these functionalized benzophenones indicate that this method may permit a novel entry to 1-phenyl-1,3-dihydroisobenzofuran derivatives.


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