TyRx Pharma Inc has developed a family of novel biocompatible and bioresorbable polyesteramides that degrade primarily through hydrolysis to water soluble, non-toxic degradants. TyRx Pharma, Inc., has received two 510K approvals for products containing members of the family containing tyrosine and other natural metabolites. In preclinical studies, these polymers have demonstrated utility as delivery system for both implantable microspheres and as coatings for medical devices, such as drug-eluting coronary stents.

Blending has been widely used in the plastics industry to produce materials whose properties are superior to those of the starting materials. Blending can be used to produce new materials that combine the useful properties of all of the constituents.

In this study, we investigated the effect of structure and concentration of the constituents on properties of blends made from TyRx's polyesteramides. Films from blends were prepared by solvent casting and the thermal, mechanical and morphological properties were determined. It was possible to obtain compatible and non-compatible blends by varying the chemistry. Results correlating polymer structure and blend properties will be presented.