Thursday, 17 May 2007: 1:50 PM-4:50 PM
Auditorium (100) (Pfahler Hall)
ADME/Tox: Drug-Drug Interactions: How to Screen for, Anticipate and Minimize Them
This session will introduce the topic of metabolic drug-drug interactions. The enzyme kinetics and pharmacokinetics of drug interactions will be presented, as this will serve as a foundation for the subsequent talks. Two presentations will describe drug interactions caused by perpetrator drugs or new chemical entities (induction and inhibition of drug-metabolizing enzymes). The fourth presentation will describe drugs and new chemical entities as victims of drug interactions. Each presentation will describe the clinical consequences of drug interactions, nonclinical (in vitro) studies and screens, and in vitro-in vivo correlations.
Sponsor: Biotage Co., Merck Research Labs
Organizer:A.David Rodrigues
Presider:A.David Rodrigues
1:50 PM319The kinetics and pharmacokinetics of drug interactions: induction, inhibition (victims and perpetrators)
Scott Obach
2:30 PM320Prediction of Human Drug-drug Interactions from In vitro Mechanism-based CYP3A4 Inhibition
Magang Shou
3:10 PM Break
3:30 PM321Induction of drug-metabolizing enzymes: In vitro studies, IVIVC and the emerging role of xenosensors in endobiotic homeostasis
Andrew Parkinson
4:10 PM322Reaction Phenotyping: In Vitro Studies and In Vitro- In Vivo Correlations
Hongjian Zhang

Back to The Middle Atlantic Regional Meeting (May 16 - 18, 2007)