Wednesday, 16 May 2007: 9:00 AM-11:40 AM
210 (Pfahler Hall)
Medicinal Chemistry Symposium
Recent advances in CNS Therapeutics The session contains talks focused on recent advances in central nervous system disorders with novel approaches towards solving these challenging problems. A mix of approaches that use computational chemistry, X-ray crystallography, classical SAR methods and novel synthetic chemistry will be presented.
Sponsor:	ACS Division of Medicinal Chemistry (MED), Merck Research Labs, CEM, Indofine Chemical, Varian
Organizer:	David Nugiel
Presider:	David Nugiel
9:00 AM	30		Synthesis of Novel Chromenone, Quinolone and Quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)amides: A Late-Stage Diversification Approach to Potent 5HT1B Antagonists Carey L. Horchler, John P. McCauley Jr., James E. Hall, Dean H. Snyder, W. Craig Moore, Thomas J. Hudzik, Marc J. Chapdelaine
9:40 AM	31		The Discovery of Non Transition-State Isostere BACE Inhibitors Hemaka A. Rajapakse
10:20 AM			Break
10:40 AM	32		Design and synthesis of novel norepinephrine reuptake inhibitors Lori Krim Gavrin, Paige E. Mahaney, Eugene J. Trybulski, An T. Vu, Gary P. Stack, Stephen Cohn, Douglas Jenkins, Joseph Sabatucci, Fei Ye, Michael Webb, Justin Belardi, Kimberly Sipe, Jenifer Lieter, Grace Johnston, Kevin Burroughs, Scott Cosmi, Liza Leventhal, Yingru Zhang, Cheryl Mugford, Sharon Rozenzwieg-Lipson, Brian Platt, Darleen C. Deecher
11:20 AM	33		Cyclic Urea-based 5HT1B Antagonists David Nugiel

Back to The Middle Atlantic Regional Meeting (May 16 - 18, 2007)