Wednesday, 16 May 2007: 1:50 PM-4:55 PM
210 (Pfahler Hall)
Medicinal Chemistry General Session
Sponsor: Biotage, Johnson & Johnson Process Research Division, ACS Division of Medicinal Chemistry, KNF Neuberger
Organizer:Michele C. Jetter
Presider:Michele C. Jetter
1:50 PM140Fragment Based Drug Discovery: An Enabling Technology in Modern Drug Discovery
Allen B. Reitz
2:20 PM141Rational design of Artemisinin-derived trioxane dimers that cure malaria-infected mice
Andrew S. Rosenthal, Wonsuk Chang, Sandra Sinishtaj, Kristina Borstnik, Ik-Hyeon Paik, Theresa A. Shapiro, Gary H. Posner
2:40 PM142Design, synthesis and preliminary biological evaluation of novel, highly antiproliferative, low-calcemic 23-oxa allylic type analogs of the natural hormone calcitriol
Gary H. Posner, Kimberly S. Petersen, Patrick Dolan, Thomas W. Kensler
3:00 PM143Discovery of selective agonists of somatostatin receptor subtype 2 (SSTR2): application of an iterative analogue library approach
Zhijian Zhao, M. Brad Nolt, Terrence P. McDonald, Jill W. Maxwell, Fumi Kinose, Catherine Thut, Craig W. Lindsley, Scott E. Wolkenberg
3:20 PM Break
3:40 PM144The development of highly potent indoleamine 2,3-dioxygenase (IDO) inhibitors with a pyranonaphthoquinone structure
Sanjeev Kumar, James DuHadaway, Judith LaLonde, William Malachowski, Alex Muller, George Prendergast
4:00 PM145Designing enzyme specific inhibitors with in situ click chemistry, a caveat involving low levels of product formation
Eric D. Strobel, Wensheng Lang, Gary Caldwell, Allen B. Reitz
4:20 PM147In Search of Novel Antimalarials: X-ray Structural Analysis of plasmodium falciparum Enoyl Carrier Protein Reductase and the Optmization of Triclosan Efficacy
Joel S. Freundlich, Hong-Ming Shieh, John W. Anderson, Guy A. Schiehser, David P. Jacobus, Feng Wang, Han-Chun Tsai, Mack Kuo, Min Yu, David A. Fidock, Juan-Carlos Valderramos, James C. Sacchettini, Kumar Tirruppadirpuliyur, Louis J. Nkrumah, William R. Jacobs, Jr.

Back to The Middle Atlantic Regional Meeting (May 16 - 18, 2007)