Thursday, 17 May 2007: 9:00 AM-11:40 AM
208 (Pfahler Hall)
Biological Chemistry Symposium: Serpin Structure and Mechanism
Serpin’s have been widely studied for over 30 years and significant progress has been made over the past decade on understanding the structure and mechanism of this enzyme class. The insight gained in recent years on serpin biochemistry in conjunction with advancements made on the identification and characterization of small molecule modulators of serpin function will be the focus of this session.
Sponsor:	Wyeth Pharmaceuticals, ACS Division of Biological Chemistry (BIOL)
Organizer:	Mehul Patel
Presider:	Mehul Patel
9:00 AM	247		Serine Protease Inhibitors as Molecular Sensors Daniel A. Lawrence
9:40 AM	248		Neutralization of PAI-1 by a Small Molecule Antagonist: Elucidating its Mechanism and Assessing its Antithrombotic Potential Stephen J. Gardell, James K. Hennan, Thomas A. Antrilli, Hassan Elokdah, Julie A. Krueger, Scott Mayer, Gwen A. Morgan, Steven J. Orcutt, Robert E. Swillo, George P. Vlasuk, David L. Crandall
10:20 AM			Break
10:40 AM	249		The inhibition of caspases by the serpin, CrmA, follows the standard serpin mechanism but with novel consequences for the regulation of caspase activity Steven Olson, Richard Swanson, Jozsef Dobo, Guy Salvesen, Peter G. W. Gettins
11:20 AM	250		Baculovirus p35 is a precursor of a Kunitz-type cyclotide inhibitor Ling Xiong, Bryan Severyn, Charles P. Scott

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