Antipsychotic drugs are one of the mostly used medications and, similar to drugs of abuse, are usually administrated for a long period of time. Due to accumulation and trap of drugs, hair provides a useful indication of long-term exposure to drugs. Micro-ATR spectroscopic methods can examine the structural changes of the hair sample by applying sufficient pressure and without microtoming the hair sample.

In this investigation, female hair samples (before and after dyed) were spiked externally with two different antipsychotic drugs, Clozapine and Haloperidol and their respective effect at different PH ranges (PH: 2.0, 7.0, 9.0) on the structure of the hair samples was observed.