This presentation will describe an interdisciplinary course on The Art and Science of Color taught at Carnegie Mellon University. The course is offered to Chemistry and Art students and focuses on the intersection of painting with chemistry. The course activities are designed to expand the expertise of students in each discipline, while exposing them to the methods, demands, and aims of the other. Historically, the craft of painting was linked to the practice of pigment preparation, with painters procuring their materials in raw form from chemists/apothecaries, and performing themselves the final purification and grinding of the minerals into pigments. With the advent of mass-produced art materials in the nineteenth century, the distance between chemist and artist increased until the two worlds have little to do with one another. This class aims to reconnect the two disciplines for a study of their common ground. Students learn about the origin of the color of minerals with primary focus on colors that originate from electronic transitions. They work collaboratively in the chemistry laboratory to synthesize and characterize inorganic pigments. In the studio, they make their own egg-tempera paints, and use them in painting projects designed to increase color skills as they learn about the history of pigment use. Students collaboratively work on final projects that involve research, experiments, and creative work. Researchers who work at the boundary between art and chemistry give guest lectures, and the class makes field trips to local research labs and museums.