Colloidosomes have a wide range of applications including cell encapsulation, imaging and diagnostics, and drug delivery. They consist of an aqueous polymer core with a shell of colloidal particles adsorbed to the surface by electrostatic interactions. The distribution and packing of the colloidal particles determine the pore size. Poly (N-isopropylacrylamide) (PNIPAAm) and alginate hydrogels are used as two different aqueous gel scaffolds, synthesized via microfluidics. The shells consist of packed polystyrene spheres which are functionalized to yield the appropriate charge. Temperature and pH sensitive polymers allow the packing of the colloidal particles to be tuned. Modifying the pore size can be particularly useful in drug delivery applications that require localization.