Our research is focused on challenging the paradigm of iterative synthesis for the preparation of complex molecules. A major objective of this program is to advance strategies that achieve rapid generation of molecular complexity via the prosecution of multiple distinct catalytic cycles in a single reaction vessel, an area of research we call multicatalysis. In these endeavors, we aim (1) to discover new chemical technologies that are amenable to incorporation in multicatalytic processes, and (2) to develop versatile multicatalytic strategies that allow for the preparation of biologically relevant organic architectures with unprecedented efficiency. In this lecture, some of our efforts towards developing multicatalytic strategies to access complex oxygen heterocycles will be discussed, as well as our discovery of several useful new chemical technologies that enable these novel approaches.