This lecture will focus on opportunities for complex particles and patterned substrates for applications in the life science and in material science areas using a novel fabrication method called PRINT (Particle Replication In Non-wetting Templates).� PRINT takes advantage of the unique properties of elastomeric molds comprised of a low surface energy perfluoropolyether network, allowing the production of monodisperse, shape-specific nanoparticles and particle arrays from an extensive range of organic and inorganic liquid precursors.���

Life Science:� We are taking a pharmaco-engineering systems approach to develop the next generation of delivery systems with programmable, multi-functional capability.� PRINT allows for the precise control over particle size, shape, composition, cargo, modulus and surface properties.� Extensive in vitro and in vivo studies have begun focused on fundamental cellular uptake and intra-cellular trafficking of particles; in vivo biodistribution; and in vivo tissue and cellular targeting.

Material Science: Opportunities for PRINT in advanced material science applications include the development a novel robotic system whose dimensions and physical properties have the ability to adapt and reversibly change from solid- to liquid-like. We envision a system that can be structurally rigid but, on command, �dissolves� into a state that is highly malleable. The basic science behind this approach relies on the fact that granular materials undergo dramatic changes in rigidity at the so-called jamming transition.� In addition to particle jamming, the discussion will focus on the details for roll-to-roll processing, application of PRINT in patterned arrays and films for use in structural composites, electrets and photovoltaics.