Monday, May 19, 2008
Student Union Building, Upper (Queensborough Community College)
299

Incorporation of Cisplatin, Carboplatin and Oxaliplatin into a Trinuclear Iron-Platinum Intervalent Charge Transfer Complex: Options for the Photochemical Delivery of Drug to Targeted Sites

Kate Keets and Andrew Bocarsly. Princeton University, Princeton, NJ

Cisplatin is a highly effective and widely used chemotherapeutic treatment with severe negative side effects. Incorporation of the drug into the trinuclear intervalent charge transfer complex [L2(CN)2FeII-(CN)-PtIV(Cl2(NH3)2)-(NC)-FeII(CN)2L2]2+ (L= 2,2'-bipyridine or 1,10-phenanthroline) allows for the release of cisplatin upon irradiation into the IVCT band of the trinuclear complex. Thus, these trinuclear compounds can be used as molecular masking agents for drug delivery, minimizing side effects. Complexes containing the second and third generation platinum drugs carboplatin and oxaliplatin have also been synthesized. Excitation of the broad absorption band ranging from 460 to 500nm in these complexes results in complex degradation and the photoproducts [FeIIIL2(CN)2]+ and [PtII(NH3)2(OH2)2]2+. Photoproduct identity has been obtained using IR spectroscopy and cyclic voltammetry.