In this experiment, the synthesis of a series of substituted benzofuran-2-carboxylic acid ethyl esters will be described under microwave-assisted conditions. Microwave-assisted organic synthesis allows not only for the improvement of reaction yields but also decreases reaction time. Microwave assisted organic synthesis help shorten the synthesis and isolation of the product and in turn, reduces environmental hazards.

A variety of substituted salicylaldehyde and �-halogenated ethyl acetate esters (X) were combined using a phase-transfer agent, different microwavable solvents, and bases. The synthetic conditions for this base-catalyzed cyclocondensation reaction will be discussed.

The scope of the reaction is being worked under several different modifications of the protocol in hopes of increasing reaction yields. The desired product for this synthesis is a heterocycle compound; heterocycles are an important class of organic compounds because of their biological activity and industrial importance.