A family of 1,4-dihydropyridines (1,4-DHP) were synthesized via the Hantzsch condensation reaction using microwave energy. The synthesis of this 1,4-DHP compounds was optimized from a variety of aldehydes, urea and ethylacetoacetonate. Most of these products commercially synthesized and serve as a main ingredient in drugs for treatment of high blood pressure. It also function as a �calcium channel blockers� to prevent heart failure and arterial aneurysm.