Adaickapillai Mahendran1, David Aebisher1, Konstantin Astafurov1, Rafael Ovalle1, Akira Kawamura2, Ernest Boamah2, Jill Bargonetti2, and Alexander Greer1. (1) City University of New York, Brooklyn College, Brooklyn, NY, (2) City University of New York, Hunter College, New York, NY
Benzopentasulfane (o-C6H4S5) possesses biological activity, but has poor water solubility. o-C6H4S5 is sparingly soluble even in DMSO (2.03 mg/mL), which has led to difficulties in evaluating the bioactivity. In DMSO, o-C6H4S5 displays IC50 100 ng/mL activity against mammalian Leukemia (Jurkat) cells, 1-10 mg/mL activity against Saccharomyces cerevisiae (X2180), and 0.1 �g/ml (10 �M) cytotoxicity to DLD-1 cancer cells absent of the p53 protein.