Inflammatory responses to alkane/alkyl polymeric materials, extensively used to replace nonfunctional body parts, have been noted. Purification of the alkane polymers from the site of inflammation revealed extensive �in vivo� oxidation as detected by fourier transformed infra-red spectroscopy. Herein, we report the novel observation that oxidized alkane polymers could induce activation of TLR1/2 pathway as determined by ligand dependent changes in intrinsic tyrosine fluorescence intensity. Molecular docking of the oxidized alkanes designated ligand specificity and polymeric conformations fitting into the TLR1/2 binding grooves. This is the first report of a synthetic polymer that could activate immune responses through TLR binding.