Clinical chemistry in its most basic sense relates abnormal values of chemical parameters to one or more disease state(s). With the recent rise in new methodologies due to the discovery of new proteins and their antibodies, clinical chemistry is in a state of flux where new information from the new methodologies are being integrated with old information.

The present talk is a brief overview of the foundation of classical clinical chemistry parameters with the known disease states. It is a review of clinical chemistry 101 and it is intended to be informative of our annual physical biochemical test.