Extensive progress has been made in the field of developing polymers based on DNA, proteins and other organic molecules as building blocks. Here we propose a novel approach of generating block co-polymers based on the self-assembly of α-helical peptides that can be induced. The coiled-coil region of cartilage oligomeric matrix protein (COMPcc) forms a homopentamer and consists of a 73 � long hydrophobic pore with a diameter of 2-6 � that is capable of binding of various hydrophobic molecules. ZE and ZR are two α-helical leucine zipper peptides that forms a heterodimer. Fusions of ZE and ZR to COMPcc results in the formation of pentameric COMPcc flanked by the zippers. We have designed block fusions of COMPcc-ZE-COMPcc and ZR-COMPcc that can be triggered to assemble upon mixing. Such bioinspired polymers possess great potential as artificial scaffolds in tissue engineering.