Nitrogen mustards (HN2) are a cytotoxic class of bifunctional alkylating agents that form various DNA crosslinks. Among the adducts that form in the reaction of these compounds with DNA, interstrand crosslinks (ICLs) cause the greatest cytotoxicity to the cell. ICLs form covalent bridges between two complementary strands of DNA inhibiting essential processes such as DNA replication and transcription. Various DNA repair pathways, including NER, homologous recombination and translesion synthesis work together to repair ICLs, but the details of how repair is achieved are not understood. In particular, the relationship between the structure of the ICL and its repair are not known. Investigating the effect due to variations of length and charge on these ICLs may lead to a better understanding of the recognition pathways involved in crosslink repair. In this work we use computational methods to investigate and predict helical distortions caused from various ICLs.