Wool, composed of keratin protein, has complex morphology and chemistry. Wool is easily damaged by conventional processing methods at all stages of its fabrication from yarn to fabric, and through dyeing and finishing. To obviate these effects and improve the properties of wool, we have been exploring nanoparticle systems that can strongly adsorb to wool without the need for chemical pre-treatments. Nanoparticle wool stands to benefit from the myriad of exciting properties that exist in the nano-domain that are not observed for bulk materials. Recently, we have prepared colloidal silver nanoparticles of varying diameter and structure using solubilized proteins as stabilizers. Initial testing of the colloidal nanoparticles has shown a marked antimicrobial efficacy toward Staphylococcus aureus. Furthermore, we observed that the stabilized nanoparticles are easily applied to wool and cotton, they impart the yellow-orange color associated with surface plasmon resonance and remain adsorbed after rinsing. These discoveries lay the foundation for extending our investigation to antimicrobial wool. Our approach, using functional stabilizers to deliver nanoparticles to materials, can be extended to other nanoparticle systems and offers an exciting opportunity for integrating nanotechnology and textiles. Here we will discuss the morphology of our colloidal silver nanoparticles, the characterization of our materials, their antimicrobial efficacy, and their sorption to wool.