Monday, May 19, 2008: 8:30 AM-12:10 PM
Medical Arts Building, Rm M-136 (Queensborough Community College)
Analysis of Biomolecules
Advances in proteomics and genomics have led to a greater emphasis on the analysis and characterization of biomolecules such as phosphopeptides, monoclonal antibodies, proteins, and SiRNa. There are many analytical technologies available for the determination of the chemical purity, aggregation, physical characteristics, and conformational state of biomolecules as well as studying how the folding/stability of these biomolecules impact biological function. This symposium will discuss the current state of application of these technologies and strategies for analysis of biomolecules from both an academic and pharmaceutical perspective.
Sponsor: Novartis Pharmaceuticals Corporation and the ACS Division of Analytical Chemistry
Organizers:Rosario LoBrutto
Richard Thompson
8:30 AM171Analytical Ultracentrifugation Analysis in the Biopharmaceutical Drug Development Process
Steven A. Berkowitz
9:00 AM172Application of Light Scattering for Analysis of Protein-Protein Interaction and Aggregation
Ewa Folta-Stogniew
9:30 AM173Hydrogen/Deuterium Exchange: Probing Conformational Changes in Proteins upon Microwave Irradiation by Electrospray Ionization Mass Spectrometry
Birendra N. Pramanik
10:00 AM174Phosphopeptide Analysis by Directly Coupling 2D Pec/tlc with MALDI-TOFMS
Ira S. Krull
10:30 AM Break
10:40 AM175Ultrasonic Storage Modulus as a Novel Parameter for Analyzing Protein-Protein Interactions in High Protein Concentration Solutions
Devendra Kalonia
11:10 AM176Unraveling the Mystery of the Analysis of the Aggregation Behavior of a Non-Covalently Self-Associating Peptide
Raymond S. McGill, Joseph Valente, Jennifer S Pickett, Vipan Taneja, Rosario LoBrutto
11:40 AM177The Impact of Conformational Fluctuations on the Analysis and Design of Protein Pharmaceuticals
Vincent J. Hilser

Back to The 40th Middle Atlantic Regional Meeting (MARM) (May 17�21, 2008)