Superciritical fluid chromatography has shown higher efficiency, higher thorughput and most importantly, its green chemistry advantages compared to conventional HPLC techniques. Pharmaceutical industry has invested heavily from the the beginning of this century to implement SFC technology to support drug discovery as well as process research.

in this presentation the theories and distinguish adavantages from SFC will be discussed based on comparison with HPLC, the practical instrumentation, implementation and practices will be demontrated for the green technological benefits that has realized so far in pharmaceutical industry, and various hyphenated SFC techniques will be introduced. the future development will also be outlined.