The statistical definition of entropy is introduced in the first days of a two-semester physical chemistry course and then relied on as the unifying theme for the entire curriculum. Early on, students are introduced to the statistical interpretation of molecular behavior and then encouraged throughout the year to make connections between concepts and interpret chemical behavior from a molecular perspective. Through this approach to the curriculum, students experience and learn the many, often disparate, concepts of physical chemistry as a more cohesive field of study. An outline highlighting the sequence of topics and pedagogical rationale of this novel approach will be presented and discussed.