Drug-eluting stents are composed of an active pharmaceutical ingredient within a polymer matrix. The device is designed to elute the drug over a long period of time in the body. As part of the chemical characterization of the formulation, an understanding of the spatial distribution of components is required. Confocal Raman microscopy is a powerful tool to nondestructively characterize drug-polymer stent coatings. In this work we generated a set of formulation standards to predict the concentration of drug and polymers found in the CYPHER^� Sirolimus-eluting Coronary Stent. The quantitative models were tested on independent sample sets to gage the accuracy and precision of the predictions.