Friday, 18 May 2007: 9:00 AM-12:00 PM
107 (Pfahler Hall)
Protein Structure: Unfolded States & Local Disruptions
Unfolded proteins and peptides have become a major focus of biochemical and biophysical research. One of the classical dogmas of protein science was that proteins have to adopt a well defined structure in order to function. However, due to the work of Dunker, Wright, Usversky and others a large number of proteins and peptides have been identified which are naturally unfolded and still function. In addition to biologically functioning unfolded molecules some of proteins/peptides have been identified, which are unfolded and prone to aggregation into fibrils which are involved in diseases like Parkinson. Additionally, the unfolded state of naturally folded peptides and proteins has attracted a lot of attention owing to the fact that it might be much less disordered than assumed. The three invited speakers cover different areas of research in this newly emerging field. Dr. Schwalbe, who is one of leading NMR-scientists in Europe, will talk about how to use NMR to explore the structure of unfolded proteins. Dr. Garcia is a theoretician, he will talk about the aggregation of the (unfolded) beta-amyloid peptide (the reason for Alzheimers) and Dr. Raleigh will address the issue of how random an unfolded state really is. Contributed papers are welcome.
Organizer:Reinhard Schweitzer-Stenner
Presider:Reinhard Schweitzer-Stenner
9:00 AM446NMR Spectroscopy to study Non-Natives States of Proteins and Structural Transitions
H. Schwalbe
9:40 AM447Probing the solution structure of the Alzheimer's peptides?
Angel E. Garcia, Nikolaos G. Sgourakis, Yilin Yan, Scott McCallum, Chunyu Wang
10:20 AM Break
10:40 AM448Just How Random is the Unfolded State? Cooperative Coupling in the Unfolded State of Globular Proteins
Daniel P. Raleigh, Jae-Hyun Cho, Satoshi Sato, Eun Young Kim, Hermann Schindelin
11:20 AM449Structure and dynamics of proteins from designed combinatorial libraries
Abigail Go, Seho Kim, Jean Baum, Michael H. Hecht
11:40 AM450Replacement of zinc with iron in the CCHHC domains of NZF-1 does not disrupt DNA binding
Niall D. Lue Sue, Sarah L. J. Michel, Holly J. Cymet

Back to The Middle Atlantic Regional Meeting (May 16 - 18, 2007)